Orthotopic Glioblastoma Models for Evaluation of the Clinical Target Volume Concept.

ABSTRACT: In times of high-precision radiotherapy, the accurate and precise definition of the primary tumor localization and its microscopic spread is of enormous importance. In glioblastoma, the microscopic tumor extension is uncertain and, therefore, population-based margins for Clinical Target Volume (CTV) definition are clinically used, which could either be too small-leading to increased risk of loco-regional recurrences-or too large, thus, enhancing the probability of normal tissue toxicity. Therefore, the aim of this project is to investigate an individualized definition of the CTV in preclinical glioblastoma models based on specific biological tumor characteristics. The microscopic tumor extensions of two different orthotopic brain tumor models (U87MG_mCherry; G7_mCherry) were evaluated befo

SUBMITTER: Butof R 

PROVIDER: S-EPMC9559695 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature