Comprehensive analysis of m⁷G modification patterns based on potential m⁷G regulators and tumor microenvironment infiltration characterization in lung adenocarcinoma.

ABSTRACT: Background: The non-negligible role of epigenetic modifications in cancer development and tumor microenvironment (TME) has been demonstrated in recent studies. Nonetheless, the potential regulatory role of N7-methylguanosine (m⁷G) modification in shaping and impacting the TME remains unclear. Methods: A comprehensive analysis was performed to explore the m⁷G modification patterns based on 24 potential m⁷G regulators in 817 lung adenocarcinoma (LUAD) patients, and the TME landscape in distinct m⁷G modification patterns were evaluated. The m⁷G score was established based on principal component analysis (PCA) to quantify m⁷G modification patterns and evaluate the TME cell infiltrating characteristics of individual

SUBMITTER: Ma S 

PROVIDER: S-EPMC9559715 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature