Multiparametric 3-D analysis of bone and joint space width at the knee from weight bearing computed tomography.

ABSTRACT:

Objective

Computed tomography (CT) can deliver multiple parameters relevant to osteoarthritis. In this study we demonstrate that a 3-D multiparametric approach at the weight bearing knee with cone beam CT is feasible, can include multiple parameters from across the joint space, and can reveal stronger relationships with disease status in combination.

Design

33 participants with knee weight bearing CT (WBCT) were analysed with joint space mapping and cortical bone mapping to deliver joint space width (JSW), subchondral bone plate thickness, endocortical thickness, and trabecular attenuation at both sides of the joint. All data were co-localised to the same canonical surface. Statistical parametric mapping (SPM) was applied in uni- and multivariate models to demonstrate signif

SUBMITTER: Turmezei TD 

PROVIDER: S-EPMC9559750 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature