Management after initial surgery of nonfunctioning pituitary adenoma: surveillance, radiotherapy or surgery?

ABSTRACT:

Introduction

The first line of treatment for nonfunctioning pituitary adenoma (NFPA) is surgery. Adjuvant radiotherapy or surveillance and new treatment (second surgical operation or salvage radiotherapy) in case of recurrence are options discussed at the multidisciplinary tumor board. The purpose of this study was to evaluate the therapeutic outcome for each option.

Methods

The records of 256 patients followed with NFPA between 2007 and 2018 were retrospectively reviewed. Mean age at initial surgery was 55 years [18-86]. Post-operative MRI found a residual tumor in 87% of patients. Mean follow-up was 12.1 years [0.8-42.7].

Results

After initial surgery, 40 patients had adjuvant radiotherapy. At 5, 10 and 15 years progression-free survival (PFS) was significantly diff

SUBMITTER: Charleux T 

PROVIDER: S-EPMC9559766 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature