Implications of Porphyromonas gingivalis peptidyl arginine deiminase and gingipain R in human health and diseases.

ABSTRACT: Porphyromonas gingivalis is a major pathogenic bacterium involved in the pathogenesis of periodontitis. Citrullination has been reported as the underlying mechanism of the pathogenesis, which relies on the interplay between two virulence factors of the bacterium, namely gingipain R and the bacterial peptidyl arginine deiminase. Gingipain R cleaves host proteins to expose the C-terminal arginines for peptidyl arginine deiminase to citrullinate and generate citrullinated proteins. Apart from carrying out citrullination in the periodontium, the bacterium is found capable of citrullinating proteins present in the host synovial tissues, atherosclerotic plaques and neurons. Studies have suggested that both virulence factors are the key factors that trigger distal effects mediated by citru

SUBMITTER: Chow YC 

PROVIDER: S-EPMC9559808 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature