Reduced activity of parvalbumin-positive interneurons in the posterior parietal cortex causes visually dominant multisensory decisions in freely navigating mice.

ABSTRACT: Multisensory integration is vital for animals to make optimal decisions in a complicated sensory environment. However, the neural mechanisms for flexible multisensory behaviors are not well understood. Here, we found that mice exhibit auditory-dominant decisions in the head-fixed and stationary state and switch to make visual-dominant decisions in the freely navigating state to resolve audiovisual conflicts. To understand the neural mechanism of the state-dependent switch in multisensory decisions, we performed in vivo calcium imaging of parvalbumin-expressing (PV⁺) inhibitory neurons in the posterior parietal cortex (PPC), which are known to mediate auditory dominance in the resolution of audiovisual conflicts, in mice on the treadmill. In the stationary state, the PPC PV⁺

SUBMITTER: Choi I 

PROVIDER: S-EPMC9559816 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature