Recognition of fold- and function-specific sites in the ligand-binding domain of the thyroid hormone receptor-like family.

ABSTRACT:

Background

The thyroid hormone receptor-like (THR-like) family is the largest transcription factors family belonging to the nuclear receptor superfamily, which directly binds to DNA and regulates the gene expression and thereby controls various metabolic processes in a ligand-dependent manner. The THR-like family contains receptors THRs, RARs, VDR, PPARs, RORs, Rev-erbs, CAR, PXR, LXRs, and others. THR-like receptors are involved in many aspects of human health, including development, metabolism and homeostasis. Therefore, it is considered an important therapeutic target for various diseases such as osteoporosis, rickets, diabetes, etc.

Methods

In this study, we have performed an extensive sequence and structure analysis of the ligand-binding domain (LBD) of the THR-like fam

SUBMITTER: Verma S 

PROVIDER: S-EPMC9559826 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature