Identification pyroptosis-related gene signature to predict prognosis and associated regulation axis in colon cancer.

ABSTRACT: Background: Pyroptosis is an important component of the tumor microenvironment and associated with the occurrence and progression of cancer. As the expression of pyroptosis-related genes and its impact on the prognosis of colon cancer (CC) remains unclear, we constructed and validated a pyroptosis-related genes signature to predict the prognosis of patients with CC. Methods: Microarray datasets and the follow-up clinical information of CC patients were obtained from the Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA) databases. Candidate genes were screened out for further analysis. Various methods were combined to construct a robust pyroptosis-related genes signature for predicting the prognosis of patients with CC. Based on the gene signature and clinical f

SUBMITTER: Zhou K 

PROVIDER: S-EPMC9559861 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature