Retinal and Choroidal Changes in Men Compared with Women with Alzheimer's Disease: A Case-Control Study.

ABSTRACT:

Purpose

To evaluate differences in the retinal microvasculature and structure and choroidal structure among men and women with Alzheimer's disease (AD) compared with age-matched cognitively normal male and female controls.

Design

Case-control study of participants ≥ 50 years of age.

Participants

A total of 202 eyes of 139 subjects (101 cases and 101 controls).

Methods

All participants and controls underwent OCT and OCT angiography (OCTA), and parameters of subjects with AD were compared with those of cognitively normal controls.

Main outcome measures

The foveal avascular zone (FAZ) area, vessel density (VD), and perfusion density (PD) in the superficial capillary plexus within the 3- and 6-mm circle and ring using Early Treatment Diabetic Retinopathy Stu

SUBMITTER: Mirzania D 

PROVIDER: S-EPMC9559893 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature