Subtractive genomic analysis for computational identification of putative immunogenic targets against clinical Enterobacter cloacae complex.

ABSTRACT:

Background

Enterobacter is a major nosocomial genus of Enterobacteriaceae responsible for a variety of nosocomial infections, particularly in prolonged hospitalized patients in the intensive care units. Since current antibiotics have failed treating colistin- and carbapenem-resistant Enterobacteriaceae, efforts are underway to find suitable alternative strategies. Therefore, this study conducted a reverse vaccinology (RV) to identify novel and putative immunogenic targets using core proteome of 20 different sequence types (STs) of clinical Enterobacter spp. Moreover, we introduced a structural-based approach for exploration of potential vaccine candidates against the Enterobacteriaceae family using their conserved domain analysis.

Results

A number of 2616 core coding sequenc

SUBMITTER: Bolourchi N 

PROVIDER: S-EPMC9560131 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature