The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function.

ABSTRACT: BTB domain And CNC Homolog 2 (Bach2) is a transcription repressor that actively participates in T and B lymphocyte development, but it is unknown if Bach2 is also involved in the development of innate immune cells, such as natural killer (NK) cells. Here, we followed the expression of Bach2 during murine NK cell development, finding that it peaked in immature CD27⁺CD11b⁺ cells and decreased upon further maturation. Bach2 showed an organ and tissue-specific expression pattern in NK cells. Bach2 expression positively correlated with the expression of transcription factor TCF1 and negatively correlated with genes encoding NK effector molecules and those involved in the cell cycle. Lack of Bach2 expression caused changes in chromatin accessibility of corresponding genes.

SUBMITTER: Li S 

PROVIDER: S-EPMC9560152 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature