The cardiopharyngeal mesoderm contributes to lymphatic vessel development in mouse.

ABSTRACT: Lymphatic vessels are crucial for tissue homeostasis and immune responses in vertebrates. Recent studies have demonstrated that lymphatic endothelial cells (LECs) arise from both venous sprouting (lymphangiogenesis) and de novo production from non-venous origins (lymphvasculogenesis), which is similar to blood vessel formation through angiogenesis and vasculogenesis. However, the contribution of LECs from non-venous origins to lymphatic networks is considered to be relatively small. Here, we identify the Islet1 (Isl1)-expressing cardiopharyngeal mesoderm (CPM) as a non-venous origin of craniofacial and cardiac LECs. Genetic lineage tracing with Isl1^Cre/+ and Isl1^CreERT2/+ mice suggested that a subset of CPM cells gives rise to LECs. These C

SUBMITTER: Maruyama K 

PROVIDER: S-EPMC9560160 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature