Comprehensive analyses reveal the role of histone deacetylase genes in prognosis and immune response in low-grade glioma.

ABSTRACT: Many studies have shown that Histone deacetylases (HDAC) is involved in the occurrence of malignant tumors and regulates the occurrence, proliferation, invasion, and migration of malignant tumors through a variety of signaling pathways. In the present, we explored the role of Histone deacetylases genes in prognosis and immune response in low-grade glioma. Using consensus clustering, we built the new molecular clusters. Using HDAC genes, we constructed and validated the prognostic model in two independent cohort datasets. Patients were divided into high-risk and low-risk groups. Then, we explored the molecular characteristics, clinical characteristics, tumor microenvironment and immune infiltration levels of two clusters and risk groups. Receiver operating characteristic analyses were built

SUBMITTER: Shen L 

PROVIDER: S-EPMC9560174 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature