High risk APOL1 genotypes and kidney disease among treatment naive HIV patients at Kano, Nigeria.

ABSTRACT:

Introduction

Racial disparities are known in the occurrence of kidney disease with excess risks found among people of African descent. Apolipoprotein L1 (APOL1) gene variants G1 and G2 are associated with kidney disease among HIV infected individuals of African descent in the USA as well as among black population in South Africa. We set out to investigate the prevalence of these high-risk variants and their effects on kidney disease among HIV infected patients in Northern Nigeria with hitherto limited information despite earlier reports of high population frequencies of these alleles from the Southern part of the country.

Methods

DNA samples obtained from the whole blood of 142 participants were genotyped for APOL1 G1 and G2 variants after initial baseline investigations inc

SUBMITTER: Abdu A 

PROVIDER: S-EPMC9560498 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature