Role of fluid-phase complement system regulation in the development of hepatitis C virus-associated glomerulonephritis.

ABSTRACT:

Objectives

It is not known why only some hepatitis C virus (HCV) infected patients develop glomerulonephritis (GN). Therefore, we investigated the role of soluble complement regulators in the development of HCV associated GN.

Methods

Patients with HCV associated GN who were admitted to our nephrology unit between July 2016 and July 2018 were recruited to the study (group 1). Two other age and sex matched groups were studied as control groups: patients with HCV without GN (group 2) and healthy HCV negative volunteers (group 3). There were 26 participants in each of the three groups at the end of the recruitment period. An assay of serum fluid-phase complement regulators was performed using enzyme linked immunosorbent assay technique. Three complement single nucleotide polymor

SUBMITTER: Ibrahim ST 

PROVIDER: S-EPMC9560510 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature