Homocysteine is associated with higher risks of ischemic stroke: A systematic review and meta-analysis.

ABSTRACT:

Background

High levels of homocysteine (Hct) have been associated with great risks of ischemic stroke. However, some controversy still exists. We performed a systematic review and meta-analysis to compare the levels of Hct between patients with ischemic stroke and controls.

Methods

We performed a systematic literature search for articles reporting Hct levels of patients with occurrence of ischemic stroke. We employed a random-effects inverse-variance weighted meta-analytical approach in order to pool standardized mean differences, with estimation of τ2 through the DerSimonian-Laird method.

Results

The initial search yielded 1361 studies. After careful analysis of abstracts and full texts, the meta-analysis included data from 38 studies, which involved almost 16 000 st

SUBMITTER: Rabelo NN 

PROVIDER: S-EPMC9560514 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature