The impact of castration on physiological responses to exertional heat stroke in mice.

ABSTRACT:

Introduction

The capability of male mice to exercise in hot environments without succumbing to exertional heat stroke (EHS) is markedly blunted compared to females. Epidemiological evidence in humans and other mammals also suggests some degree of greater vulnerability to heat stroke in males compared to females. The origins of these differences are unknown, but testosterone has previously been shown to induce faster elevations in core temperature during acute, passive heat exposure. In this study, we tested the hypothesis that loss of testosterone and related sex hormones through castration would improve the performance and heat tolerance of male mice during EHS exposure.

Methods

Twenty-four male mice were randomly divided into 3 groups, untreated EHS mice (SHAM-EHS), castra

SUBMITTER: Garcia CK 

PROVIDER: S-EPMC9560521 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature