Reconstructing long-term dengue virus immunity in French Polynesia.

ABSTRACT:

Background

Understanding the underlying risk of infection by dengue virus from surveillance systems is complicated due to the complex nature of the disease. In particular, the probability of becoming severely sick is driven by serotype-specific infection histories as well as age; however, this has rarely been quantified. Island communities that have periodic outbreaks dominated by single serotypes provide an opportunity to disentangle the competing role of serotype, age and changes in surveillance systems in characterising disease risk.

Methodology

We develop mathematical models to analyse 35 years of dengue surveillance (1979-2014) and seroprevalence studies from French Polynesia. We estimate the annual force of infection, serotype-specific reporting probabilities and chang

SUBMITTER: Nemoto T 

PROVIDER: S-EPMC9560594 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature