Genetic variants determine intrafamilial variability of SARS-CoV-2 clinical outcomes in 19 Italian families.

ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection results in a wide range of outcomes characterized by a high heterogeneity in both symptomatology and susceptibility to the disease. In such a perspective, COVID-19 may be considered as a multifactorial disease featured by the interaction between the environment, which is the virus itself, and the genetic profile of the host. Our analysis aimed at investigating the transmission dynamics of SARS-CoV-2 within families whose members responded in different ways to the infection, although the exposure was common to the entire group and occurred before the availability of any vaccine. The goal was to understand how the genetic background of each subject can influence the viral infection outcome and hence the above-mentioned cl

SUBMITTER: Azzara A 

PROVIDER: S-EPMC9560599 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature