Integrated analyses of brain and platelet omics reveal their common altered and driven molecules in Alzheimer's disease.

ABSTRACT: Platelets may serve as a perfect peripheral source for exploring diagnostic biomarkers for Alzheimer's disease (AD); however, the molecular linkage between platelet and the brain is missing. To find the common altered and driving molecules in both brain and the platelet, we performed an integrated analysis of our platelet omics and brain omics reported in the literature, and analyzed their correlations with AD-specific pathology and cognitive impairment. By integrating the gene and protein expression profiles from 269 AD patients, we deduced 239 differentially expressed proteins (DEPs) appeared in both brain and the platelet, and 70.3% of them had consistent changes. Further analysis demonstrated that the altered brain and peripheral regulations were pinpointed into 10 imbalanced pathways.

SUBMITTER: Yu H 

PROVIDER: S-EPMC9560744 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature