Guanosine modulates K⁺ membrane currents in SH-SY5Y cells: involvement of adenosine receptors.

ABSTRACT: Guanosine (GUO), widely considered a key signaling mediator, is implicated in the regulation of several cellular processes. While its interaction with neural membranes has been described, GUO still is an orphan neuromodulator. It has been postulated that GUO may eventually interact with potassium channels and adenosine (ADO) receptors (ARs), both particularly important for the control of cellular excitability. Accordingly, here, we investigated the effects of GUO on the bioelectric activity of human neuroblastoma SH-SY5Y cells by whole-cell patch-clamp recordings. We first explored the contribution of voltage-dependent K⁺ channels and, besides this, the role of ARs in the regulation of GUO-dependent cellular electrophysiology. Our data support that GUO is able to specifically mo

SUBMITTER: Gambino G 

PROVIDER: S-EPMC9560947 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature