Nascent transcriptome reveals orchestration of zygotic genome activation in early embryogenesis.

ABSTRACT: Early embryo development requires maternal-to-zygotic transition, during which transcriptionally silent nuclei begin widespread gene expression during zygotic genome activation (ZGA).^1-3 ZGA is vital for early cell fating and germ-layer specification,^3,4 and ZGA timing is regulated by multiple mechanisms.^1-5 However, controversies remain about whether these mechanisms are interrelated and vary among species^6-10 and whether the timing of germ-layer-specific gene activation is temporally ordered.^11,12 In some embryonic models, widespread ZGA onset is spatiotemporally graded,^13,14 yet it is unclear whether the transcriptome follows this pattern. A major challenge

SUBMITTER: Chen H 

PROVIDER: S-EPMC9560990 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature