Comparison of inflammatory and behavioral responses to chronic stress in female and male mice.

ABSTRACT: Major depressive disorder (MDD) is a debilitating disease with a high worldwide prevalence. Despite its greater prevalence in women, male animals are used in most preclinical studies of depression even though there are many sex differences in key components of depression, such as stress responses and immune system functions. In the present study, we found that chronic restraint stress-induced depressive-like behaviors are quite similar in male and female mice, with both sexes displaying increased immobility time in the tail suspension test and reduced social interactions, and both sexes exhibited deficits in working and spatial memories. However, in contrast to the similar depressive-like behaviors developed by male and female mice in response to stress, they displayed different patterns o

SUBMITTER: Medina-Rodriguez EM 

PROVIDER: S-EPMC9561002 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature