Precision medicine for genetic epilepsy on the horizon: Recent advances, present challenges, and suggestions for continued progress.

ABSTRACT: The genetic basis of many epilepsies is increasingly understood, giving rise to the possibility of precision treatments tailored to specific genetic etiologies. Despite this, current medical therapy for most epilepsies remains imprecise, aimed primarily at empirical seizure reduction rather than targeting specific disease processes. Intellectual and technological leaps in diagnosis over the past 10 years have not yet translated to routine changes in clinical practice. However, the epilepsy community is poised to make impressive gains in precision therapy, with continued innovation in gene discovery, diagnostic ability, and bioinformatics; increased access to genetic testing and counseling; fuller understanding of natural histories; agility and rigor in preclinical research, including strat

SUBMITTER: Knowles JK 

PROVIDER: S-EPMC9561034 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature