Carrier-free supramolecular nanoassemblies of pure LSD1 inhibitor for effective anti-tumor therapy.

ABSTRACT: The LSD1 protein is an oxidase that regulates protein methylation, which regulates gene expression and triggers tumors. Previously, inhibiting LSD1 has been found to be an effective treatment strategy for opposing tumors caused by overexpression of LSD1. Our recent study found that compound 17i was a suitable LSD1 inhibitor with potential anti-tumor activity. However, its extremely insoluble nature limits further validation of its anti-tumor activity at the clinical level. In this study, a unique carrier-free supramolecular nanoassemblies of pure compound 17i is expected to enhance therapeutic efficacy. Aqueous-insoluble compound 17i was mixed with a small quantity of DSPE-PEG₂₀₀₀ into an organic solvent and was prepared as nanoassemblies in water via the on

SUBMITTER: Li B 

PROVIDER: S-EPMC9561089 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature