Diverse selection pressures shaping the genetic architecture of behcet disease susceptibility.

ABSTRACT: Behçet disease (BD) is a polygenic, multifactorial, multisystem inflammatory condition with unknown etiology. Global distribution of BD is geographically structured, highest prevalence observed among East Asian, Middle Eastern, and Mediterranean populations. Although adaptive selection on a few BD susceptibility loci is speculated, a thorough evolutionary analysis on the genetic architecture of BD is lacking. We aimed to understand whether increased BD risk in the human populations with high prevalence is due to past selection on BD associated genes. We performed population genetics analyses with East Asian (high BD prevalence), European (low/very low BD prevalence), and African (very low/no BD prevalence) populations. Comparison of ancestral and derived alleles' frequencies versus their r

SUBMITTER: Sezgin E 

PROVIDER: S-EPMC9561091 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature