Intermittent hypoxia inhibits epinephrine-induced transcriptional changes in human aortic endothelial cells.

ABSTRACT: Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular disease. While intermittent hypoxia (IH) and catecholamine release play an important role in this increased risk, the mechanisms are incompletely understood. We have recently reported that IH causes endothelial cell (EC) activation, an early phenomenon in the development of cardiovascular disease, via IH-induced catecholamine release. Here, we investigated the effects of IH and epinephrine on gene expression in human aortic ECs using RNA-sequencing. We found a significant overlap between IH and epinephrine-induced differentially expressed genes (DEGs) including enrichment in leukocyte migration, cytokine-cytokine receptor interaction, cell adhesion and angiogenesis. Epinephrine caused higher number of DEGs compa

SUBMITTER: Cetin-Atalay R 

PROVIDER: S-EPMC9561121 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature