The Association Between Metabolic Syndrome and Colorectal Cancer Risk by Obesity Status in Korean Women: A Nationwide Cohort Study.

ABSTRACT:

Objectives

This study aimed to determine the association between metabolic syndrome (MetS) and the incidence of colorectal cancer (CRC) in Korean women with obesity.

Methods

Cancer-free women (n=6 142 486) aged 40-79 years, who underwent National Health Insurance Service health examinations in 2009 and 2010 were included. The incidence of CRC was followed until 2018. The hazard ratio (HR) of MetS for the incidence of colon and rectal cancer was analyzed according to body mass index (BMI) categories, adjusting for confounders such as women's reproductive factors. In addition, the heterogeneity of associations across BMI categories was assessed.

Results

Women with MetS were at increased risk of colon and rectal cancer compared to women without MetS (HR, 1.20; 95% confid

SUBMITTER: Moon SG 

PROVIDER: S-EPMC9561145 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature