Elderly CADASIL patients with intact neurological status.

ABSTRACT:

Background and purpose

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is one of the most devastating cerebral small vessel diseases. However, despite its progression with aging, some patients remain neurologically intact (Nint) even when they get older. Their main characteristics are poorly known. We aimed to delineate their clinical, imaging, and molecular features.

Methods

Individuals aged over 65 years were selected from a cohort of 472 CADASIL patients. Subjects who had no focal deficit, cognitive impairment, or disability were considered Nint. Their demographic, genetic, clinical, and imaging features were compared to those with permanent neurological symptoms (Nps).

Results

Among 129 patients, 23 (17.8%) indi

SUBMITTER: Zhang R 

PROVIDER: S-EPMC9561215 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature