Early indicators of neonatal-onset hereditary thrombotic thrombocytopenia purpura.

ABSTRACT:

Background

Neonatal-onset hereditary thrombotic thrombocytopenia purpura (hTTP) is often misdiagnosed due to its rarity. It begins with jaundice, similar to infants with ABO incompatibility.

Objective

To explore early indicators of neonatal-onset hTTP.

Methods

This study was a retrospective case series of newborns with hTTP and ABO incompatibility. We compared the clinical characteristics and laboratory test results in these two groups.

Results

This study included four hTTP patients and 20 ABO-incompatible newborns. All patients manifested disease during the neonatal period. There were equal numbers of males and females in each group. hTTP newborns showed earlier (median difference, 57.0 h; 95% confidence interval [CI], 24.0-65.0) and more severe hyperbilirubin

SUBMITTER: Liu J 

PROVIDER: S-EPMC9561421 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature