A non-human primate model of acute liver failure suitable for testing liver support systems.

ABSTRACT: Acute hepatic failure is associated with high morbidity and mortality for which the only definitive therapy is liver transplantation. Some fraction of those who undergo emergency transplantation have been shown to recover native liver function when transplanted with an auxiliary hepatic graft that leaves part of the native liver intact. Thus, transplantation could have been averted with the development and use of some form of hepatic support. The costs of developing and testing liver support systems could be dramatically reduced by the availability of a reliable large animal model of hepatic failure with a large therapeutic window that allows the assessment of efficacy and timing of intervention. Non-lethal forms of hepatic injury were examined in combination with liver-directed radiation

SUBMITTER: Kalsi RS 

PROVIDER: S-EPMC9561471 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature