A new obligate CXCL4–CXCL12 heterodimer for studying chemokine heterodimer activities and mechanisms

ABSTRACT: Chemokines form a family of proteins with critical roles in many biological processes in health and disease conditions, including cardiovascular, autoimmune diseases, infections, and cancer. Many chemokines engage in heterophilic interactions to form heterodimers, leading to synergistic activity enhancement or reduction dependent on the nature of heterodimer-forming chemokines. In mixtures, different chemokine species with diverse activities coexist in dynamic equilibrium, leading to the observation of their combined response in biological assays. To overcome this problem, we produced a non-dissociating CXCL4–CXCL12 chemokine heterodimer OHD4–12 as a new tool for studying the biological activities and mechanisms of chemokine heterodimers in biological environments. Using the OHD4–12, we sh

SUBMITTER: Nguyen K 

PROVIDER: S-EPMC9561612 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature