Guidance landscapes unveiled by quantitative proteomics to control reinnervation in adult visual system.

ABSTRACT: In the injured adult central nervous system (CNS), activation of pro-growth molecular pathways in neurons leads to long-distance regeneration. However, most regenerative fibers display guidance defects, which prevent reinnervation and functional recovery. Therefore, the molecular characterization of the proper target regions of regenerative axons is essential to uncover the modalities of adult reinnervation. In this study, we use mass spectrometry (MS)-based quantitative proteomics to address the proteomes of major nuclei of the adult visual system. These analyses reveal that guidance-associated molecules are expressed in adult visual targets. Moreover, we show that bilateral optic nerve injury modulates the expression of specific proteins. In contrast, the expression of guidance molecules

SUBMITTER: Vilallongue N 

PROVIDER: S-EPMC9561644 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature