Serum CD14 concentration is associated with obesity and insulin resistance in non-diabetic individuals.

ABSTRACT:

Objective

CD14 is a lipopolysaccharide-binding protein that serves as a marker of monocytes. The role of circulating CD14 in patients with obesity without diabetes remains unknown. Here, we characterized the relationships between serum CD14 concentration and metabolic parameters related to diabetes and obesity.

Methods

We performed an observational, prospective case-control study. Eighty participants were evaluated: 26 drug-naïve patients with type 2 diabetes mellitus and 54 healthy individuals. We compared the circulating CD14 concentration and metabolic parameters of the participants with and without diabetes.

Results

The circulating CD14 concentration did not significantly differ between the two groups, but was lower in participants with obesity than in lean contro

SUBMITTER: Kang YE 

PROVIDER: S-EPMC9561661 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature