Structure-activity relationships of Toxoplasma gondii cytochrome bc₁ inhibitors.

ABSTRACT:

Introduction

Toxoplasma gondii is a prolific apicomplexan parasite that infects human and nonhuman animals worldwide and can cause severe brain and eye disease. Safer, more effective therapies for toxoplasmosis are needed. Cytochrome bc₁ inhibitors are remarkably effective against toxoplasmosis and other apicomplexan-caused diseases.

Areas covered

This work reviews T. gondii cytochrome bc₁ inhibitors. Emphasis is placed on the structure-activity relationships of these inhibitors with regard to efficacy, pharmacokinetics, selectivity of T. gondii cytochrome bc₁ over host, safety, and potential therapeutic strategies.

Expert opinion

Cytochrome bc₁ inhibitors are highly promising

SUBMITTER: Alday PH 

PROVIDER: S-EPMC9561756 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature