Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer.
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ABSTRACT:
SUBMITTER: Tang M
PROVIDER: S-EPMC9561794 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Publications
Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer.
Tang Meng M Xu Hui H Huang Hongyan H Kuang Hao H Wang Chenxi C Li Qinqin Q Zhang Xin X Ge Yizhong Y Song Mengmeng M Zhang Xi X Wang Ziwen Z Ma Chaobing C Kang Jinlin J Zhang Wanfang W Wang You Y Zhang Bo B Zhang Xiaowei X Chen Yongbing Y Cong Minghua M Melino Gerry G Wang Xiaobin X Zhou Fuxiang F Sun Qiang Q Shi Hanping H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20220828 29
Although targeting cancer metabolism is a promising therapeutic strategy, clinical success depends on accurate molecular and metabolic subtyping. Here, this study reports two metabolism-based molecular subtypes associated with the ketogenic treatment of colon cancer: glycolytic (glycolysis<sup>+</sup> /ketolysis<sup>-</sup> ) and ketolytic (glycolysis<sup>+</sup> /ketolysis<sup>+</sup> ), which are manifested by distinct profiles of metabolic enzymes and mitochondrial dysfunction, and by differe ...[more]
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