Genetic and immune crosstalk between severe burns and blunt trauma: A study of transcriptomic data.

ABSTRACT: Background: Severe burns and blunt trauma can lead to multiple organ dysfunction syndrome, the leading cause of death in intensive care units. In addition to infection, the degree of immune inflammatory response also affects prognosis. However, the characteristics and clinical relevance of the common mechanisms of these major diseases are still underexplored. Methods: In the present study, we performed microarray data analysis to identify immune-related differentially expressed genes (DEGs) involved in both disease progression in burns and blunt trauma. Six analyses were subsequently performed, including gene enrichment analysis, protein-protein interaction (PPI) network construction, immune cell infiltration analysis, core gene identification, co-expression network analysis,

SUBMITTER: Chen X 

PROVIDER: S-EPMC9561827 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature