Increased PRR14 and VCAM-1 level in serum of patients with Parkinson's disease.

ABSTRACT:

Background

Regarding the complexity of Parkinson's disease (PD), the identification of reliable biomarkers is of great significance for improving the accuracy of diagnosis and monitoring disease progression. Recently, some studies suggested that serum proline-rich protein 14 (PRR14), vascular cell adhesion molecule-1 (VCAM-1), and soluble CD163 (sCD163) factors may be associated with PD, even as potential biomarkers. However, the role of these serum factors is still unclear.

Objectives

This study aimed to explore the alterations of serum PRR14, VCAM-1, and sCD163 levels during PD progression, and their association with disease-related variables of PD.

Methods

We performed the assessment of scale tests and the detection of serum samples in patients with PD (n =

SUBMITTER: Zheng H 

PROVIDER: S-EPMC9561935 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature