Association of Changes in Cancer Therapy Over 3 Decades With Risk of Subsequent Breast Cancer Among Female Childhood Cancer Survivors: A Report From the Childhood Cancer Survivor Study (CCSS).

ABSTRACT:

Importance

Breast cancer is the most common invasive subsequent malignant disease in childhood cancer survivors, though limited data exist on changes in breast cancer rates as primary cancer treatments have evolved.

Objective

To quantify the association between temporal changes in cancer treatment over 3 decades and subsequent breast cancer risk.

Design, setting, and participants

Retrospective cohort study of 5-year cancer survivors diagnosed when younger than 21 years between 1970 and 1999, with follow-up through December 5, 2020.

Exposures

Radiation and chemotherapy dose changes over time.

Main outcomes and measures

Breast cancer cumulative incidence rates and age-specific standardized incidence ratios (SIRs) compared across treatment decades (1970-199

SUBMITTER: Henderson TO 

PROVIDER: S-EPMC9562103 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature