Cervical immune activation during the luteal phase may compromise subsequent trans-cervical ram sperm transport†.

ABSTRACT: Worldwide, cervical artificial insemination using frozen-thawed semen yields low pregnancy rates. The only exception to this is in Norway, where vaginal insemination with frozen-thawed semen yields pregnancy rates in excess of 60% and which has been attributed to the specific ewe breed used. Our previous work demonstrated differences in cervical gene expression at the follicular phase of the estrous cycle in ewe breeds with known differences in pregnancy rates. In this study, we characterized the cervical transcriptome of the same ewe breeds [Suffolk, Belclare, Fur, and Norwegian White Sheep (NWS)] during the luteal phase, as an optimal environment at the luteal phase could better prepare the cervix for sperm migration through the cervix at the subsequent follicular phase. High-quality RNA

SUBMITTER: Abril-Parreno L 

PROVIDER: S-EPMC9562110 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature