Natural killer cells-related immune traits and amyotrophic lateral sclerosis: A Mendelian randomization study.

ABSTRACT:

Background

Observational studies have suggested that peripheral immune disorders are associated with amyotrophic lateral sclerosis (ALS). Previous studies predominantly focused on changes in adaptive immunity. However, emerging evidence showed natural killer (NK) cells, an essential component of innate immunity, were involved in the degeneration of motor neurons. However, the causal relationship between dysregulated NK cells-related immune traits and ALS remains unclear.

Objective

This study aimed to explore the causal relationship between NK cells-related immune traits and the risk of ALS.

Materials and methods

Single nucleotide polymorphisms (SNPs) significantly associated with NK cells-related immune traits were selected as instrumental variables to estimate their

SUBMITTER: Gong Z 

PROVIDER: S-EPMC9562140 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature