Whole-Abdomen Metabolic Imaging of Healthy Volunteers Using Hyperpolarized [1-¹³ C]pyruvate MRI.

ABSTRACT:

Background

Hyperpolarized ¹³ C MRI quantitatively measures enzyme-catalyzed metabolism in cancer and metabolic diseases. Whole-abdomen imaging will permit dynamic metabolic imaging of several abdominal organs simultaneously in healthy and diseased subjects.

Purpose

Image hyperpolarized [1-¹³ C]pyruvate and products in the abdomens of healthy volunteers, overcoming challenges of motion, magnetic field variations, and spatial coverage. Compare hyperpolarized [1-¹³ C]pyruvate metabolism across abdominal organs of healthy volunteers.

Study type

Prospective technical development.

Subjects

A total of 13 healthy volunteers (8 male), 21-64 years (median 36).

Field strength/sequence

A 3 T. Proton: T₁ -weighted spoiled g

SUBMITTER: Lee PM 

PROVIDER: S-EPMC9562149 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature