Oncogenic Role of ADAM32 in Hepatoblastoma: A Potential Molecular Target for Therapy.

ABSTRACT: Outcomes of pediatric hepatoblastoma (HBL) have improved, but refractory cases still occur. More effective and safer drugs are needed that are based on molecular mechanisms. A disintegrin and metalloproteases (ADAMs) are expressed with high frequency in various human carcinomas and play an important role in cancer progression. In this study, we analyzed expression of ADAMs in HBL with a cDNA microarray dataset and found that the expression level of ADAM32 is particularly high. To investigate the role of ADAM32 in cancer, forced expression or knockdown experiments were conducted with HepG2 and HBL primary cells. Colony formation, cell migration and invasion, and cell viability were increased in HepG2 expressing ADAM32, whereas knockdown of ADAM32 induced a decrease in these ce

SUBMITTER: Fukazawa T 

PROVIDER: S-EPMC9562177 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature