Avoiding Pitfalls in Thermal Dose Effect Relationship Studies: A Review and Guide Forward.

ABSTRACT: The challenge to explain the diffuse and unconclusive message reported by hyperthermia studies investigating the thermal dose parameter is still to be unravelled. In the present review, we investigated a wide range of technical and clinical parameters characterising hyperthermia treatment to better understand and improve the probability of detecting a thermal dose effect relationship in clinical studies. We performed a systematic literature review to obtain hyperthermia clinical studies investigating the associations of temperature and thermal dose parameters with treatment outcome or acute toxicity. Different hyperthermia characteristics were retrieved, and their influence on temperature and thermal dose parameters was assessed. In the literature, we found forty-eight articles investigati

SUBMITTER: Carrapico-Seabra C 

PROVIDER: S-EPMC9562191 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature