PAX8 Expression in the Crystalline Lens and Lens-Derived Lesions.

ABSTRACT:

Purpose

To evaluate PAX8 expression by immunohistochemistry in the normal pediatric and adult crystalline lens and to assess the usefulness of PAX8 immunohistochemical stain in the diagnosis of morphologically challenging lesions of lenticular origin.

Design

Retrospective, observational case series.

Participants

Fourteen congenital and acquired lens-derived lesions and 10 control crystalline lenses.

Methods

Hematoxylin-eosin and periodic acid-Schiff stains and an immunohistochemical panel of PAX8, vimentin, S100, smooth muscle actin, AE1/AE3, cytokeratin 7, and cytokeratin 5/6 antibodies were performed on all tissues.

Main outcome measures

Distribution of PAX8 expression in normal crystalline lens and in lens-derived lesions.

Results

Records searc

SUBMITTER: Milman T 

PROVIDER: S-EPMC9562292 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature