Folding and Duplex Formation in Sequence-Defined Aniline Benzaldehyde Oligoarylacetylenes.

ABSTRACT: In all known genetic polymers, molecular recognition via hydrogen bonding between complementary subunits underpins their ability to encode and transmit information, to form sequence-defined duplexes, and to fold into catalytically active forms. Reversible covalent interactions between complementary subunits provide a different way to encode information, and potentially function, in sequence-defined oligomers. Here, we examine six oligoarylacetylene trimers composed of aniline and benzaldehyde subunits. Four of these trimers self-pair to form two-rung duplex structures, and two form macrocyclic 1,3-folded structures. The equilibrium proportions of these structures can be driven to favor each of the observed structures almost entirely depending upon the concentration of trimers and an acid c

SUBMITTER: Strom KR 

PROVIDER: S-EPMC9562438 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature