Targeted Depletion of Hyaluronic Acid Mitigates Murine Breast Cancer Growth.

ABSTRACT: Hyaluronic acid (HA) is highly elevated in breast cancers compared to normal breast tissue and is associated with increased tumor aggressiveness and poor prognosis. HA interacts with cell-trafficking CD44 receptors to promote tumor cell migration and proliferation and regulates both pro- and anti-inflammatory cytokine production through tumor-associated macrophages. The highly negative charge of HA enables its uptake of vast amounts of water that greatly increases the tumor interstitial fluidic pressure, which, combined with the presence of other extracellular matrix components such as collagen, results in tumor stroma with abnormal vasculature, hypoxia, and increased drug resistance. Thus, the degradation of HA in breast cancer may attenuate growth and improve permeability to anticancer a

SUBMITTER: Zamloot V 

PROVIDER: S-EPMC9562634 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature