Combined BRCA2 and MAGEC3 Expression Predict Outcome in Advanced Ovarian Cancers.

ABSTRACT: Like BRCA2, MAGEC3 is an ovarian cancer predisposition gene that has been shown to have prognostic significance in ovarian cancer patients. Despite the clinical significance of each gene, no studies have been conducted to assess the clinical significance of their combined expression. We therefore sought to determine the relationship between MAGEC3 and BRCA2 expression in ovarian cancer and their association with patient characteristics and outcomes. Immunohistochemical staining was quantitated on tumor microarrays of human tumor samples obtained from 357 patients with epithelial ovarian cancer to ascertain BRCA2 expression levels. In conjunction with our previously published MAGEC3 expression data, we observed a weak inverse correlation of MAGEC3 with BRCA2 expression (r = −0.15; p < 0.05)

SUBMITTER: Omole EB 

PROVIDER: S-EPMC9562635 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature