Dose optimisation and scarce resource allocation: two sides of the same coin.

ABSTRACT:

Objective

A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines.

Summary of key data

The vast majority of drug development and repurposing during the COVID-19 pandemic - an event that has made clear the ever-present scarcity in healthcare systems -has been ignorant of scarcity and dose optimisation's ability to help address it.

Conclusions

Future pandemic clinical trials systems should obtain dose optimisation data, as these appear necessary to enable appropriate scarce resource allocation according to societal values.

SUBMITTER: Strohbehn G 

PROVIDER: S-EPMC9562718 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature