Hypothyroidism has a protective causal association with hepatocellular carcinoma: A two-sample Mendelian randomization study.

ABSTRACT:

Objective

Observational studies suggest an association between hypothyroidism and the risk of hepatocellular carcinoma (HCC), but the causality and direction of these effects are still inconclusive. We aim to test whether hypothyroidism is causally associated with the risk of HCC by using Mendelian randomization (MR) analysis.

Methods

Single-nucleotide polymorphisms (SNPs) associated with hypothyroidism were screened via a genome-wide association study (GWAS) on 337,159 individuals of European descent (16,376 cases and 320,783 controls). The SNPs associated with thyroid-stimulating hormone (TSH) and free thyroxine (FT4) were selected from a GWAS of 72,167 individuals of European descent. Summary-level data for HCC (168 cases and 372,016 controls) were extracted from U

SUBMITTER: Lu L 

PROVIDER: S-EPMC9562779 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature